Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | BUB1 | O43683 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | ROS1 | P08922 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.58 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.58 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.58 |
| ▸ | MERTK | Q12866 | 1/20 | 0.58 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.58 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.58 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.58 |
| ▸ | MAP3K2 | Q9Y2U5 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14956500 | 0.87 | LRRK2 (0.68) | SYKKCNH2JAK2PAK4ROS1 | |
| SCHEMBL16743187 | 0.86 | SYK (0.76) | SYKKCNH2AURKBBUB1JAK2 | |
| SCHEMBL14839136 | 0.86 | SYK (0.79) | SYKKCNH2AURKBBUB1JAK2 | |
| SCHEMBL16743283 | 0.84 | SYK (0.68) | SYKKCNH2AURKB | |
| SCHEMBL16743258 | 0.84 | SYK (0.71) | SYKKCNH2AURKB | |
| SCHEMBL16743175 | 0.83 | SYK (0.73) | SYKKCNH2AURKBBUB1JAK2 | |
| SCHEMBL14909606 | 0.82 | SYK (0.56) | SYKKCNH2AURKB | |
| SCHEMBL14909607 | 0.82 | SYK (0.56) | SYKKCNH2AURKB | |
| SCHEMBL16743160 | 0.82 | SYK (0.68) | SYKKCNH2AURKBBUB1JAK2 | |
| SCHEMBL16743209 | 0.82 | SYK (0.70) | SYKKCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |