Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743268 | 0.92 | SYK (0.74) | SYKAURKBMAPK3MAPK1KCNH2 | |
| SCHEMBL16743356 | 0.89 | SYK (0.61) | SYKAURKBMAPK3MAPK1KCNH2 | |
| SCHEMBL16743365 | 0.87 | SYK (0.65) | SYKAURKBMAPK3MAPK1KCNH2 | |
| SCHEMBL16743155 | 0.87 | SYK (0.72) | SYKAURKBMAPK3MAPK1KCNH2 | |
| SCHEMBL14838959 | 0.83 | SYK (0.78) | SYKAURKBMAPK3MAPK1KCNH2 | |
| SCHEMBL16743287 | 0.83 | SYK (0.70) | SYKAURKBMAPK3MAPK1KCNH2 | |
| SCHEMBL14839058 | 0.83 | SYK (1.00) | SYKAURKBMAPK3MAPK1KCNH2 | |
| Hydrochloric Acid SCHEMBL15911009 | 0.82 | SYK (0.98) | SYKAURKBMAPK3MAPK1KCNH2 | |
| SCHEMBL16743284 | 0.82 | SYK (0.71) | SYKAURKBMAPK3MAPK1KCNH2 | |
| SCHEMBL16253471 | 0.81 | SYK (0.80) | SYKAURKBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |