SCHEMBL16744444

SCHEMBL16744444

C=C=Nc1ccc(Cc2cc(Cc3ccc(N=C=O)cc3)ccc2N=C=O)cc1

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.57
TSHR P16473 1/20 0.57
CYP1A2 P05177 1/20 0.48
TRPA1 O75762 1/20 0.37
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2877352 0.93 CYP3A4 (0.67) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL16417864 0.93 CYP3A4 (0.67) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL3024606 0.93 CYP3A4 (0.67) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL374837 0.85 CYP3A4 (0.63) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL1104238 0.84 CYP3A4 (0.80) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL1396314 0.84 CYP3A4 (0.54) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL10635526 0.84 CYP3A4 (0.62) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL11345977 0.83 CYP3A4 (0.57) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL19598808 0.82 CYP3A4 (0.51) CYP3A4TSHRCYP1A2TRPA1
SCHEMBL13743147 0.82 CYP3A4 (0.65) CYP3A4TSHRCYP1A2TRPA1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150148449-A1 Polyurethane-based Waterproofing Composition for the Water-proofing of Concrete Structures VERIFI LLC 2015-05-28 US disclosed