Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | STAT1 | P42224 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 8/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.65 |
| ▸ | ACP1 | P24666 | 1/20 | 0.65 |
| ▸ | SCD | O00767 | 1/20 | 0.64 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.63 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.60 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375443 | 0.88 | SCD (0.69) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL11161571 | 0.88 | KMT2A (0.73) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL30493298 | 0.88 | DYRK1A (0.70) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL3949427 | 0.88 | DYRK1A (0.70) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL3924050 | 0.87 | DYRK1A (1.00) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL9332797 | 0.85 | KMT2A (0.77) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL16732745 | 0.85 | DYRK1A (0.78) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL31349444 | 0.84 | KMT2A (0.68) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL31349449 | 0.84 | KMT2A (0.68) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 | |
| SCHEMBL27566837 | 0.84 | DYRK1A (0.76) | DYRK1AKMT2ASMN1; SMN2POLBSTAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758480-B2 | 1-(cycloalkyl-carbonyl)proline derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-9758480-B2 | 1-(cycloalkyl-carbonyl)proline derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-20150210640-A1 | 1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2015-07-30 | — | — | US | disclosed |
| US-20150210640-A1 | 1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2015-07-30 | — | — | US | disclosed |
| EP-2876105-A1 | 1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2015-05-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210640-A1 | 1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE | RB1, F2, SFPQ | DYRK1A 1519/4885KMT2A 484/4885SMN1; SMN2 3586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.