Sugi Predict

Sugi Predict / Compounds / SCHEMBL16747827

SCHEMBL16747827

SCHEMBL16747827

Cc1nc2cc(F)c(F)cc2n1-c1cncc(Nc2ccc(OC(F)F)cc2)n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BMI1 P35226 10/20 0.57
▸ SCN5A Q14524 3/20 0.38
▸ SCN9A Q15858 3/20 0.38
▸ KCNH2 Q12809 2/20 0.38
▸ ROCK1 Q13464 1/20 0.38
▸ GALR2 O43603 2/20 0.37
▸ IDH1 O75874 1/20 0.36
▸ GALR1 P47211 1/20 0.36
▸ BRAF P15056 1/20 0.34
▸ SYK P43405 1/20 0.34
▸ TUBB4A P04350 1/20 0.34
▸ TUBB P07437 1/20 0.34
▸ TUBA3C P0DPH7 1/20 0.34
▸ TUBA1B P68363 1/20 0.34
▸ TUBA4A P68366 1/20 0.34
▸ TUBB4B P68371 1/20 0.34
▸ TUBB3 Q13509 1/20 0.34
▸ TUBB2A Q13885 1/20 0.34
▸ TUBB8 Q3ZCM7 1/20 0.34
▸ TUBA3E Q6PEY2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16740287 0.89 BMI1 (0.72) BMI1SCN5ASCN9AKCNH2ROCK1
SCHEMBL16740290 0.89 BMI1 (0.61) BMI1SCN5ASCN9AKCNH2ROCK1
SCHEMBL16740075 0.89 BMI1 (0.48) BMI1SCN5ASCN9AKCNH2BRAF
SCHEMBL16739941 0.88 BMI1 (0.44) BMI1GALR2GALR1BRAF
SCHEMBL16747851 0.87 BMI1 (0.53) BMI1SCN9AROCK1GALR2IDH1
SCHEMBL16747913 0.87 BMI1 (0.41) BMI1SCN5ASCN9AKCNH2BRAF
SCHEMBL16740385 0.86 BMI1 (0.53) BMI1SCN5ASCN9AKCNH2ROCK1
SCHEMBL16747973 0.86 BMI1 (0.58) BMI1SCN5ASCN9AKCNH2ROCK1
SCHEMBL16739727 0.86 BMI1 (0.45) BMI1SCN5ASCN9AKCNH2BRAF
SCHEMBL16740062 0.86 KCNH2 (0.50) BMI1SCN5ASCN9AKCNH2GALR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10584115-B2 Substituted pyridine and pyrazine BMI-1 inhibitors PTC THERAPEUTICS, INC. (US) 2020-03-10 — — US claimed
US-10584115-B2 Substituted pyridine and pyrazine BMI-1 inhibitors PTC THERAPEUTICS, INC. (US) 2020-03-10 — — US disclosed
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. 2016-09-29 — — US disclosed
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. 2016-09-29 — — US disclosed
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. 2016-09-29 — — US disclosed
WO-2015076800-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. (US) 2015-05-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS BMI1, BAZ2A, BAZ2B BMI1 1/4885SCN5A 3115/4885SCN9A 4295/4885
US-10584115-B2 Substituted pyridine and pyrazine BMI-1 inhibitors BMI1, BAZ2A, BAZ2B BMI1 1/4885SCN5A 3115/4885SCN9A 4295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.