Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 8/20 | 0.39 |
| ▸ | BCR | P11274 | 8/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16739926 | 0.90 | KCNH2 (0.47) | KCNH2SCN5ASCN9ABRAFMCHR1 | |
| SCHEMBL16739979 | 0.89 | CYP11B1 (0.44) | KCNH2SCN5ASCN9ABRAFCYP11B1 | |
| SCHEMBL16739829 | 0.89 | BRAF (0.42) | KCNH2SCN5ASCN9ABRAFCYP11B1 | |
| SCHEMBL16740250 | 0.88 | SCN5A (0.47) | KCNH2SCN5ASCN9ABRAFMCHR1 | |
| SCHEMBL16747837 | 0.87 | KCNH2 (0.42) | KCNH2SCN5ASCN9ABRAFMCHR1 | |
| SCHEMBL16747840 | 0.86 | BMI1 (0.41) | KCNH2SCN5ASCN9ABRAFCYP11B1 | |
| SCHEMBL16739953 | 0.85 | CDK2 (0.43) | KCNH2SCN5ASCN9ABRAFCYP11B1 | |
| SCHEMBL16740170 | 0.84 | CDK2 (0.42) | BRAFCYP11B1CYP11B2 | |
| SCHEMBL16740403 | 0.83 | MCHR1 (0.41) | BRAFMCHR1DHFRABL1BCR | |
| SCHEMBL16740078 | 0.83 | CYP11B1 (0.35) | KCNH2SCN5ASCN9ABRAFCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10584115-B2 | Substituted pyridine and pyrazine BMI-1 inhibitors | PTC THERAPEUTICS, INC. (US) | 2020-03-10 | — | — | US | claimed |
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | claimed |
| US-10584115-B2 | Substituted pyridine and pyrazine BMI-1 inhibitors | PTC THERAPEUTICS, INC. (US) | 2020-03-10 | — | — | US | disclosed |
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | disclosed |
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | disclosed |
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | disclosed |
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | BMI1, BAZ2A, BAZ2B | KCNH2 3952/4885SCN5A 3115/4885SCN9A 4295/4885 |
| US-10584115-B2 | Substituted pyridine and pyrazine BMI-1 inhibitors | BMI1, BAZ2A, BAZ2B | KCNH2 3952/4885SCN5A 3115/4885SCN9A 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.