Sugi Predict

Sugi Predict / Compounds / SCHEMBL16747892

SCHEMBL16747892

SCHEMBL16747892

Cc1nc2ccccc2n1-c1cncc(Nc2ccc(OC(F)(F)C(F)F)cc2)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BMI1 P35226 16/20 0.54
▸ TUBB4A P04350 2/20 0.46
▸ TUBB P07437 2/20 0.46
▸ TUBA3C P0DPH7 2/20 0.46
▸ TUBA1B P68363 2/20 0.46
▸ TUBA4A P68366 2/20 0.46
▸ TUBB4B P68371 2/20 0.46
▸ TUBB3 Q13509 2/20 0.46
▸ TUBB2A Q13885 2/20 0.46
▸ TUBB8 Q3ZCM7 2/20 0.46
▸ TUBA3E Q6PEY2 2/20 0.46
▸ TUBA1A Q71U36 2/20 0.46
▸ TUBA1C Q9BQE3 2/20 0.46
▸ TUBB6 Q9BUF5 2/20 0.46
▸ TUBB2B Q9BVA1 2/20 0.46
▸ TUBB1 Q9H4B7 2/20 0.46
▸ KCNH2 Q12809 1/20 0.42
▸ SCN5A Q14524 1/20 0.42
▸ SCN9A Q15858 1/20 0.42
▸ CCNE1 P24864 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16739749 0.91 BMI1 (0.53) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16739577 0.87 BMI1 (0.70) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16739838 0.85 BMI1 (0.58) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16739644 0.84 BMI1 (0.68) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16740157 0.84 BMI1 (0.52) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16739612 0.83 BMI1 (0.52) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16739912 0.83 BMI1 (0.69) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16739832 0.82 BMI1 (0.65) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16739615 0.82 BMI1 (0.53) BMI1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL16739876 0.80 BMI1 (0.55) BMI1TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10584115-B2 Substituted pyridine and pyrazine BMI-1 inhibitors PTC THERAPEUTICS, INC. (US) 2020-03-10 — — US claimed
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. 2016-09-29 — — US claimed
US-10584115-B2 Substituted pyridine and pyrazine BMI-1 inhibitors PTC THERAPEUTICS, INC. (US) 2020-03-10 — — US disclosed
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. 2016-09-29 — — US disclosed
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. 2016-09-29 — — US disclosed
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. 2016-09-29 — — US disclosed
WO-2015076800-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS PTC THERAPEUTICS, INC. (US) 2015-05-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160280685-A1 SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS BMI1, BAZ2A, BAZ2B BMI1 1/4885TUBB4A 2892/4885TUBB 2688/4885
US-10584115-B2 Substituted pyridine and pyrazine BMI-1 inhibitors BMI1, BAZ2A, BAZ2B BMI1 1/4885TUBB4A 2892/4885TUBB 2688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.