Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.37 |
| ▸ | BMI1 | P35226 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747849 | 0.81 | SCN5A (0.57) | SCN9ASCN5AKCNH2TDO2AGPAT2 | |
| SCHEMBL16747947 | 0.80 | KCNH2 (0.44) | SCN9ASCN5AKCNH2ALDH1A1GAA | |
| SCHEMBL16747859 | 0.79 | SCN9A (0.55) | SCN9ASCN5AKCNH2TDO2AGPAT2 | |
| SCHEMBL16739660 | 0.77 | SCN9A (0.84) | SCN9ASCN5AKCNH2TDO2AGPAT2 | |
| SCHEMBL16748025 | 0.75 | SCN5A (0.54) | SCN9ASCN5AKCNH2TDO2AGPAT2 | |
| SCHEMBL16747949 | 0.72 | SCN5A (0.56) | SCN9ASCN5AKCNH2AGPAT2BMI1 | |
| SCHEMBL16739547 | 0.71 | CDK2 (0.63) | SCN9ASCN5AKCNH2AGPAT2BMI1 | |
| SCHEMBL29420814 | 0.71 | KCNH2 (0.58) | SCN9ASCN5AKCNH2AGPAT2BMI1 | |
| SCHEMBL16748018 | 0.71 | KCNH2 (0.52) | SCN9ASCN5AKCNH2TDO2AGPAT2 | |
| SCHEMBL16740233 | 0.70 | BMI1 (0.48) | SCN9ASCN5AKCNH2AGPAT2BMI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | disclosed |
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | disclosed |
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | BMI1, BAZ2A, BAZ2B | SCN9A 4295/4885SCN5A 3115/4885KCNH2 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.