Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.59 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.53 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31439313 | 0.87 | MTOR (0.64) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL31439341 | 0.86 | MTOR (0.60) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL31439327 | 0.85 | MTOR (0.68) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL31439316 | 0.85 | MTOR (0.71) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL31439309 | 0.85 | MTOR (0.64) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL31439377 | 0.84 | MTOR (0.62) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16748295 | 0.83 | MTOR (0.68) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL31439333 | 0.83 | MTOR (0.59) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15747791 | 0.83 | MTOR (0.61) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15747818 | 0.82 | MTOR (0.87) | MTORPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3072893-A1 | KETONE DERIVATIVES OF IMIDAZOLES, PHARMACEUTICAL COMBINATIONS AND USES THEREOF | Beijing Forelandpharma Co. Ltd. (CN) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015074516-A1 | KETONE DERIVATIVES OF IMIDAZOLES, PHARMACEUTICAL COMBINATIONS AND USES THEREOF | 北京富龙康泰生物技术有限公司 | 2015-05-28 | — | — | WO | disclosed |