Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 8/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.41 |
| ▸ | MTOR | P42345 | 12/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16740761 | 0.91 | BMI1 (0.49) | BMI1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL16740796 | 0.90 | BMI1 (0.43) | BMI1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL16748532 | 0.90 | BMI1 (0.51) | BMI1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL16740825 | 0.90 | PIK3CB (0.44) | BMI1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL16740847 | 0.90 | PIK3CA (0.41) | BMI1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL16748503 | 0.89 | BMI1 (0.37) | BMI1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL16740770 | 0.88 | PIK3CB (0.40) | BMI1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL16740856 | 0.87 | BMI1 (0.50) | BMI1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL16550235 | 0.86 | BMI1 (0.56) | BMI1PIK3CAMTOR | |
| SCHEMBL15742405 | 0.86 | BMI1 (0.47) | BMI1PIK3CAMTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975878-B2 | Substituted triazine BMI-1 inhibitors | PTC THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | claimed |
| US-20160297798-A1 | SUBSTITUTED TRIAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-10-13 | — | — | US | claimed |
| US-9975878-B2 | Substituted triazine BMI-1 inhibitors | PTC THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| US-9975878-B2 | Substituted triazine BMI-1 inhibitors | PTC THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| US-9975878-B2 | Substituted triazine BMI-1 inhibitors | PTC THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| US-20160297798-A1 | SUBSTITUTED TRIAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-10-13 | — | — | US | disclosed |
| US-20160297798-A1 | SUBSTITUTED TRIAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-10-13 | — | — | US | disclosed |
| US-20160297798-A1 | SUBSTITUTED TRIAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-10-13 | — | — | US | disclosed |
| WO-2015076801-A1 | SUBSTITUTED TRIAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297798-A1 | SUBSTITUTED TRIAZINE BMI-1 INHIBITORS | BMI1, BAZ2A, BAZ2B | BMI1 1/4885PIK3CA 3534/4885MTOR 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.