Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 11/20 | 0.84 |
| ▸ | CLK1 | P49759 | 7/20 | 0.84 |
| ▸ | CLK2 | P49760 | 6/20 | 0.84 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.84 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675234 | 0.92 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL29520104 | 0.92 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675150 | 0.84 | CLK4 (0.76) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675131 | 0.84 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675183 | 0.83 | CLK4 (0.60) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675153 | 0.82 | CLK4 (0.85) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675095 | 0.81 | CLK4 (0.81) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675108 | 0.81 | CLK4 (0.62) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675054 | 0.81 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675287 | 0.81 | CLK4 (0.79) | CLK4CLK1CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |