Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.66 |
| ▸ | CLK1 | P49759 | 3/20 | 0.66 |
| ▸ | CLK2 | P49760 | 3/20 | 0.66 |
| ▸ | CLK3 | P49761 | 3/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674969 | 0.92 | CLK4 (0.68) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL29481271 | 0.81 | CLK1 (0.51) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL29481277 | 0.81 | CLK1 (0.51) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL22745193 | 0.81 | CLK1 (0.51) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL28726502 | 0.81 | CLK1 (0.51) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL28726562 | 0.81 | CLK1 (0.51) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL1675197 | 0.79 | CLK4 (1.00) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL1675200 | 0.79 | CLK4 (1.00) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL14595538 | 0.79 | CLK1 (0.66) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL13283132 | 0.77 | CLK1 (0.66) | CLK4CLK1CLK2CLK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |