Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16752808 | 1.00 | GSK3B (0.48) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL16752809 | 1.00 | GSK3B (0.48) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| Sulfuric Acid SCHEMBL16752806 | 0.97 | GSK3B (0.45) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| Sulfuric Acid SCHEMBL16752805 | 0.97 | GSK3B (0.45) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL19976769 | 0.91 | GSK3B (0.51) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL16752841 | 0.89 | GSK3B (0.46) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL16752848 | 0.89 | GSK3B (0.46) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL16769263 | 0.89 | MAPK1 (0.41) | GSK3BHDAC6MAPK1FGFR2FGFR1 | |
| SCHEMBL16769262 | 0.89 | GSK3B (0.46) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL16752844 | 0.89 | GSK3B (0.46) | GSK3BTRPA1HDAC6MAPK1MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |
| US-20150152063-A1 | INDAZOLE GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152063-A1 | INDAZOLE GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | ATP5F1A, ATP5ME, ATP5F1D | GSK3B 3708/4885TRPA1 3822/4885HDAC6 963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.