Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 10/20 | 0.68 |
| ▸ | CLK4 | Q9HAZ1 | 15/20 | 0.65 |
| ▸ | CLK2 | P49760 | 8/20 | 0.65 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.65 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675124 | 0.84 | CLK1 (0.57) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675222 | 0.83 | CLK1 (0.67) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675053 | 0.83 | CLK1 (0.64) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675115 | 0.82 | CLK1 (0.61) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675047 | 0.81 | CLK4 (0.63) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675177 | 0.81 | CLK1 (1.00) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675242 | 0.80 | CLK1 (0.73) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675337 | 0.79 | CLK4 (1.00) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675151 | 0.79 | CLK4 (0.46) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675109 | 0.71 | CLK4 (0.49) | CLK1CLK4CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |