Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.43 |
| ▸ | GALR3 | O60755 | 3/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16756257 | 0.88 | TNF (0.47) | DCTPP1GALR3NR2F2RAB9ANPC1 | |
| SCHEMBL15552701 | 0.84 | GALR3 (0.46) | GALR3NR2F2RAB9ANPC1TLR7 | |
| SCHEMBL16756239 | 0.82 | TLR7 (0.40) | DCTPP1GALR3NR2F2RAB9ANPC1 | |
| SCHEMBL18918981 | 0.82 | TLR7 (0.42) | DCTPP1GALR3NR2F2RAB9ANPC1 | |
| SCHEMBL28860467 | 0.81 | GALR3 (0.62) | GALR3NR2F2RAB9ANPC1HTT | |
| SCHEMBL16756350 | 0.80 | GALR3 (0.43) | DCTPP1GALR3NR2F2RAB9ANPC1 | |
| SCHEMBL16756466 | 0.80 | GALR3 (0.43) | DCTPP1GALR3NR2F2RAB9ANPC1 | |
| SCHEMBL16756331 | 0.79 | HPGD (0.40) | DCTPP1GALR3NR2F2RAB9AHTT | |
| SCHEMBL20258867 | 0.79 | GALR3 (0.45) | GALR3NR2F2RAB9ANPC1P2RX7 | |
| SCHEMBL16756298 | 0.79 | TNF (0.42) | DCTPP1GALR3NR2F2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858983-B1 | TNF-ALPHA MODULATING BENZIMIDAZOLES | UCB BIOPHARMA SPRL (BE) | 2018-04-18 | — | — | EP | disclosed |
| US-9550737-B2 | TNF -α modulating benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2017-01-24 | — | — | US | disclosed |
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | TNF, TNFRSF1A, NFKBIA | DCTPP1 2186/4885GALR3 4147/4885NR2F2 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.