Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | TNF | P01375 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30582653 | 1.00 | TSHR (1.00) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL15552030 | 0.87 | TSHR (0.77) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL29870044 | 0.86 | TSHR (0.76) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL28432040 | 0.86 | TSHR (0.76) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL15541163 | 0.85 | TSHR (0.73) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL15551310 | 0.84 | TSHR (0.72) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL15560565 | 0.84 | TSHR (0.72) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL15553033 | 0.82 | TSHR (0.69) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL15551873 | 0.82 | TSHR (0.69) | TSHRTNFNPC1MAPTTP53 | |
| SCHEMBL15560601 | 0.81 | TSHR (0.67) | TSHRTNFNPC1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311168-B1 | NOVEL TNF STRUCTURE FOR USE IN THERAPY | UCB Biopharma SRL (BE) | 2023-05-10 | — | — | EP | disclosed |
| US-20210088530-A1 | NOVEL TNFa STRUCTURE FOR USE IN THERAPY | UCB Biopharma SRL (BE) | 2021-03-25 | — | — | US | disclosed |
| US-10775385-B2 | Treatment of autoimmune and inflammatory disorders with asymmetric TNF alpha trimers | UCB Biopharma SRL (BE) | 2020-09-15 | — | — | US | disclosed |
| US-9550737-B2 | TNF -α modulating benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2017-01-24 | — | — | US | disclosed |
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | TNF, TNFRSF1A, NFKBIA | TSHR 1696/4885TNF 1/4885NPC1 3216/4885 |
| US-20210088530-A1 | NOVEL TNFa STRUCTURE FOR USE IN THERAPY | TNFRSF1A, TNFRSF9, CD40 | TSHR 259/4885TNF 5/4885NPC1 4061/4885 |
| US-10775385-B2 | Treatment of autoimmune and inflammatory disorders with asymmetric TNF alpha trimers | TNFRSF1A, TNFRSF9, CD40 | TSHR 218/4885TNF 4/4885NPC1 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.