Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 16/20 | 0.47 |
| ▸ | BRD2 | P25440 | 3/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16738961 | 0.79 | BRD4 (0.64) | BRD4BRD2NPBWR1MCHR1 | |
| SCHEMBL16739002 | 0.77 | BRD4 (0.64) | BRD4BRD2 | |
| SCHEMBL16738999 | 0.75 | BRD4 (0.66) | BRD4BRD2 | |
| SCHEMBL16758648 | 0.74 | BRD4 (0.50) | BRD4BRD2NPBWR1MCHR1LMNA | |
| SCHEMBL16739072 | 0.66 | BRD4 (0.56) | BRD4BRD2NPBWR1MCHR1 | |
| SCHEMBL16738899 | 0.65 | BRD4 (0.47) | BRD4BRD2 | |
| SCHEMBL16738951 | 0.64 | BRD4 (0.85) | BRD4BRD2 | |
| SCHEMBL16739055 | 0.64 | BRD4 (1.00) | BRD4BRD2 | |
| SCHEMBL16738921 | 0.64 | BRD4 (0.48) | BRD4BRD2 | |
| SCHEMBL18391561 | 0.64 | BRD4 (0.59) | BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015081203-A1 | BICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | INCYTE CORPORATION (US) | 2015-06-04 | — | — | WO | disclosed |