Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.58 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.58 |
| ▸ | SCN2B | O60939 | 1/20 | 0.58 |
| ▸ | SCN1A | P35498 | 1/20 | 0.58 |
| ▸ | SCN4A | P35499 | 1/20 | 0.58 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.58 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL16759448 | 1.00 | SCN9A (0.58) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| Trifluoroacetic Acid SCHEMBL16759618 | 1.00 | SCN9A (0.58) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL16770956 | 0.95 | SCN9A (0.62) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL17061807 | 0.95 | SCN9A (0.62) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL16771237 | 0.95 | SCN9A (0.62) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| Trifluoroacetic Acid SCHEMBL16758968 | 0.89 | SCN9A (0.76) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| Trifluoroacetic Acid SCHEMBL16758937 | 0.89 | SCN9A (0.76) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| Trifluoroacetic Acid SCHEMBL16758965 | 0.89 | SCN9A (0.76) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL28338202 | 0.88 | SCN9A (0.57) | SCN9ASCN7ASCN5ASCN2BSCN1A | |
| SCHEMBL28336579 | 0.88 | SCN9A (0.57) | SCN9ASCN7ASCN5ASCN2BSCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074377-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-10-05 | — | — | EP | disclosed |
| WO-2015078374-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-06-04 | — | — | WO | disclosed |