Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 11/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MUSK | O15146 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16207774 | 1.00 | JAK3 (0.43) | JAK3JAK2LIMK1LIMK2ROCK2 | |
| SCHEMBL16207729 | 0.93 | CYP1A2 (0.39) | JAK3JAK2LIMK1LIMK2S1PR3 | |
| SCHEMBL16207730 | 0.93 | CYP1A2 (0.39) | JAK3JAK2LIMK1LIMK2S1PR3 | |
| SCHEMBL16165005 | 0.91 | S1PR3 (0.41) | JAK3JAK2LIMK1LIMK2S1PR3 | |
| SCHEMBL16165007 | 0.91 | S1PR3 (0.41) | JAK3JAK2LIMK1LIMK2S1PR3 | |
| SCHEMBL16207782 | 0.91 | KHK (0.37) | JAK3JAK2LIMK1LIMK2S1PR3 | |
| SCHEMBL16760783 | 0.90 | S1PR3 (0.42) | JAK3JAK2LIMK1LIMK2S1PR3 | |
| SCHEMBL16207787 | 0.90 | S1PR3 (0.42) | JAK3JAK2LIMK1LIMK2S1PR3 | |
| SCHEMBL16164556 | 0.89 | JAK2 (0.35) | JAK3JAK2LIMK1LIMK2S1PR3 | |
| SCHEMBL16164554 | 0.89 | JAK2 (0.35) | JAK3JAK2LIMK1LIMK2S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051310-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2015-06-09 | — | — | US | disclosed |