Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 2/20 | 0.33 |
| ▸ | KIFC1 | Q9BW19 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1676201 | 1.00 | S1PR5 (0.37) | S1PR5ARRB1DPP4GRIN2BS1PR1 | |
| SCHEMBL1676680 | 0.93 | NPC1 (0.35) | S1PR5ARRB1DPP4GRIN2BSLC6A7 | |
| SCHEMBL1676677 | 0.93 | NPC1 (0.35) | S1PR5ARRB1DPP4GRIN2BSLC6A7 | |
| SCHEMBL1675996 | 0.90 | S1PR5 (0.38) | S1PR5GRIN2BGCGRSLC13A5 | |
| SCHEMBL1675998 | 0.90 | S1PR5 (0.38) | S1PR5GRIN2BGCGRSLC13A5 | |
| SCHEMBL1481125 | 0.89 | MEN1 (0.42) | S1PR5DPP4HDAC1HDAC6FNTA | |
| SCHEMBL1481124 | 0.89 | MEN1 (0.42) | S1PR5DPP4HDAC1HDAC6FNTA | |
| SCHEMBL1481399 | 0.88 | S1PR5 (0.42) | S1PR5DPP4GCGRFNTAPGGT1B | |
| SCHEMBL1481397 | 0.88 | S1PR5 (0.42) | S1PR5DPP4GCGRFNTAPGGT1B | |
| SCHEMBL1676380 | 0.87 | DPP4 (0.40) | S1PR5DPP4HDAC1HDAC6FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | TRANSTECH PHARMA, INC. (US) | 2011-04-21 | — | — | US | disclosed |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | PTPRO, PTPN5, PTPRE | S1PR5 3261/4885ARRB1 1194/4885DPP4 115/4885 |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | PTPRO, PTPN5, PTPRE | S1PR5 3261/4885ARRB1 1194/4885DPP4 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.