Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.47 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16768667 | 0.91 | HSP90AA1 (0.47) | HSP90AA1HSP90B1LMNASMN1; SMN2 | |
| SCHEMBL16768665 | 0.89 | HSP90AA1 (0.51) | HSP90AA1HSP90B1SMN1; SMN2ADRB1HSP90AB1 | |
| SCHEMBL16768651 | 0.88 | HSP90AA1 (0.46) | HSP90AA1HSP90B1HSP90AB1BRD4 | |
| SCHEMBL16768673 | 0.87 | HSP90B1 (0.51) | HSP90AA1HSP90B1LMNAHSP90AB1 | |
| SCHEMBL16133646 | 0.86 | HSP90B1 (0.53) | HSP90AA1HSP90B1LMNASMN1; SMN2HSP90AB1 | |
| SCHEMBL16064999 | 0.84 | HSP90AA1 (0.48) | HSP90AA1HSP90B1LMNASMN1; SMN2KCNH2 | |
| SCHEMBL16768685 | 0.83 | HSP90AA1 (0.50) | HSP90AA1HSP90B1SMN1; SMN2HSP90AB1BRD4 | |
| SCHEMBL16136332 | 0.81 | HSP90B1 (0.55) | HSP90AA1HSP90B1LMNASMN1; SMN2HSP90AB1 | |
| SCHEMBL16133645 | 0.76 | HSP90B1 (0.52) | HSP90AA1HSP90B1LMNASMN1; SMN2 | |
| SCHEMBL16133633 | 0.76 | HSP90B1 (0.49) | HSP90AA1HSP90B1LMNASMN1; SMN2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776996-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9045477-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2015-06-02 | — | — | US | disclosed |