Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 20/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16770404 | 0.89 | MME (0.60) | MME | |
| SCHEMBL23089729 | 0.83 | MME (0.65) | MME | |
| SCHEMBL9929895 | 0.83 | MME (0.65) | MME | |
| SCHEMBL16768805 | 0.82 | MME (0.61) | MMEACE | |
| SCHEMBL23089721 | 0.81 | MME (0.82) | MMEACE | |
| SCHEMBL9929761 | 0.81 | MME (0.82) | MMEACE | |
| SCHEMBL18409010 | 0.80 | MME (0.69) | MMEACE | |
| SCHEMBL18409008 | 0.80 | MME (0.69) | MMEACE | |
| SCHEMBL18427216 | 0.80 | MME (0.69) | MMEACE | |
| SCHEMBL16768804 | 0.79 | HDAC1 (0.48) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855464-B1 | NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2016-10-26 | — | — | EP | disclosed |
| US-9045443-B2 | Nitric oxide donor neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-06-02 | — | — | US | disclosed |