Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.46 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16757436 | 0.83 | KMT2A (0.82) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL16227019 | 0.83 | KMT2A (0.82) | KMT2AMEN1RAB9AALDH1A1OPRM1 | |
| SCHEMBL16757422 | 0.83 | KMT2A (0.73) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL16757295 | 0.83 | KMT2A (0.61) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL25090739 | 0.82 | KMT2A (0.47) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL24424631 | 0.82 | KMT2A (0.47) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL16757194 | 0.80 | KMT2A (0.72) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL16757213 | 0.80 | KMT2A (1.00) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL16757078 | 0.80 | KMT2A (0.64) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL16757237 | 0.79 | KMT2A (0.75) | KMT2AMEN1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170001988-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS AND CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2017-01-05 | — | — | US | disclosed |
| CN-106029060-A | piperidine and piperidine derivatives and their use in the treatment of viral infections and cancer | 美国卫生和人力服务部 | 2016-10-12 | — | — | CN | disclosed |
| WO-2015080949-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS AND CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170001988-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS AND CANCER | NCOR1, RRP15, NCOA1 | KMT2A 1974/4885MEN1 3157/4885RAB9A 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.