Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.67 |
| ▸ | TEK | Q02763 | 14/20 | 0.67 |
| ▸ | LCK | P06239 | 12/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | ABL2 | P42684 | 3/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16769955 | 0.93 | KDR (0.66) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL16769950 | 0.85 | KDR (0.63) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL16769806 | 0.83 | TEK (0.66) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL16769986 | 0.83 | KDR (0.62) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL2071955 | 0.81 | KDR (1.00) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL16769925 | 0.80 | TEK (0.61) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL16769999 | 0.80 | TEK (0.64) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL16769952 | 0.79 | TEK (0.71) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL18925744 | 0.78 | TEK (0.59) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL18925730 | 0.78 | TEK (0.51) | KDRTEKLCKSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015077866-A1 | PROTEIN KINASE INHIBITORS | PHARMASCIENCE INC. (CA) | 2015-06-04 | — | — | WO | disclosed |