SCHEMBL16770896

SCHEMBL16770896

O=C(O)c1cc(C2CC2)c(OCC2CNC2)cc1F

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.53
SCN5A Q14524 4/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28078731 0.99 SCN9A (0.52) SCN9ASCN5A
SCHEMBL30261423 0.90 SCN9A (0.61) SCN9ASCN5A
SCHEMBL28338274 0.90 SCN9A (0.57) SCN9ASCN5A
SCHEMBL28338503 0.90 SCN9A (0.57) SCN9ASCN5A
SCHEMBL28338273 0.90 SCN9A (0.57) SCN9ASCN5A
SCHEMBL16758808 0.89 SCN9A (0.55) SCN9ASCN5A
SCHEMBL15537287 0.87 SCN9A (0.67) SCN9ASCN5A
SCHEMBL15558570 0.87 SCN9A (0.55) SCN9ASCN5A
SCHEMBL16448614 0.86 SCN9A (0.69) SCN9ASCN5A
Hydrochloric Acid SCHEMBL16759474 0.86 SCN9A (0.54) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104718188-A N-substituted benzamides and their use in the treatment of pain GENENTECH INC 2015-06-17 CN disclosed
WO-2015078374-A1 SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2015-06-04 WO disclosed