Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17134793 | 0.79 | EGFR (0.60) | EGFRMEN1KMT2ALMNAMAPT | |
| SCHEMBL17135155 | 0.78 | EGFR (0.51) | EGFRMEN1KMT2ALMNAMAPT | |
| SCHEMBL1342083 | 0.77 | MAP2K1 (0.53) | MEN1KMT2ASMN1; SMN2HTTNPC1 | |
| SCHEMBL17134561 | 0.77 | EGFR (0.49) | EGFRMEN1KMT2ALMNAMAPT | |
| SCHEMBL17134960 | 0.75 | GAA (0.55) | EGFRMEN1KMT2ALMNAMAPT | |
| SCHEMBL17134923 | 0.75 | EGFR (0.59) | EGFRMEN1KMT2ALMNAMAPT | |
| SCHEMBL16774938 | 0.70 | MEN1 (0.38) | EGFRMEN1KMT2ALMNAMAPT | |
| SCHEMBL16803290 | 0.70 | MAP2K1 (0.48) | EGFRMEN1KMT2ALMNAMAPT | |
| SCHEMBL17134938 | 0.69 | MAP2K1 (0.47) | EGFRMAP2K1CSF1R | |
| SCHEMBL17134619 | 0.69 | MAP2K1 (0.53) | MAPTALDH1A1GAAMAP2K1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121620-B1 | INHIBITORS OF MEK | ARDEA BIOSCIENCES INC (US) | 2015-06-17 | — | — | EP | disclosed |