Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 11/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.91 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.63 |
| ▸ | LCK | P06239 | 5/20 | 0.63 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.63 |
| ▸ | INSR | P06213 | 2/20 | 0.63 |
| ▸ | FYN | P06241 | 2/20 | 0.63 |
| ▸ | YES1 | P07947 | 2/20 | 0.63 |
| ▸ | LYN | P07948 | 2/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.63 |
| ▸ | MET | P08581 | 2/20 | 0.63 |
| ▸ | ROS1 | P08922 | 2/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.63 |
| ▸ | BRAF | P15056 | 2/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.63 |
| ▸ | FLT1 | P17948 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374681 | 0.95 | FGFR3 (1.00) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL4767225 | 0.95 | FGFR3 (0.82) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL374374 | 0.90 | FGFR3 (0.90) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL16774660 | 0.90 | FGFR3 (0.74) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL2015731 | 0.89 | FGFR3 (0.87) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL4763496 | 0.88 | FGFR3 (0.70) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL374509 | 0.86 | FGFR3 (0.83) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL377378 | 0.86 | FGFR3 (0.83) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL2011654 | 0.84 | FGFR3 (0.80) | FGFR3CYP3A4FGFR1LCKFGFR4 | |
| SCHEMBL2012837 | 0.84 | FGFR3 (0.65) | FGFR3CYP3A4FGFR1LCKFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976847-B1 | PYRIMIDINYL ARYL UREA DERIVATIVES BEING FGF INHIBITORS | NOVARTIS AG (CH) | 2015-06-17 | — | — | EP | claimed |