Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 5/20 | 0.66 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 8/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595046 | 0.89 | FYN (0.66) | FYNPIM1RETPIM2SLC2A1 | |
| SCHEMBL4337397 | 0.86 | PIK3CG (0.62) | FYNJAK2PIM1RETJAK3 | |
| SCHEMBL4335453 | 0.86 | FYN (0.82) | FYNJAK2PIM1PIM2JAK3 | |
| SCHEMBL4338182 | 0.85 | FYN (0.69) | FYNPIM1RETPIM2PIK3CG | |
| SCHEMBL4325795 | 0.84 | JAK3 (0.66) | FYNJAK2PIM1JAK3PTK2 | |
| SCHEMBL4692793 | 0.84 | FYN (0.65) | FYNJAK2PIM1RETJAK3 | |
| SCHEMBL4340112 | 0.84 | FYN (0.67) | FYNJAK2PIM1RETJAK3 | |
| SCHEMBL4338231 | 0.84 | PIM1 (0.67) | FYNPIM1PIM2 | |
| SCHEMBL102515 | 0.84 | FYN (0.62) | FYNJAK2PIM1RETJAK3 | |
| SCHEMBL4338988 | 0.84 | BRAF (0.64) | FYNJAK2RETJAK3SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086979-B1 | IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2015-06-03 | — | — | EP | disclosed |