Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 6/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9288995 | 0.93 | CHRM3 (0.61) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL8512408 | 0.89 | CHRM3 (0.65) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL8512405 | 0.89 | CHRM3 (0.65) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL8510174 | 0.88 | CHRM3 (0.63) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL8510178 | 0.88 | CHRM3 (0.63) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL12071819 | 0.88 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL1695933 | 0.88 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL1695975 | 0.88 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL1695935 | 0.88 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECYP2D6 | |
| SCHEMBL2486482 | 0.88 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077385-B1 | HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARM SPA (IT) | 2017-10-04 | — | — | EP | disclosed |
| US-9133185-B2 | Heteroaryl derivatives | CHIESI FARMACEUTICI S.P.A (IT) | 2015-09-15 | — | — | US | disclosed |
| US-9133185-B2 | Heteroaryl derivatives | CHIESI FARMACEUTICI S.P.A (IT) | 2015-09-15 | — | — | US | disclosed |
| US-20150158858-A1 | HETEROARYL DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | US | disclosed |
| WO-2015082616-A1 | HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | WO | disclosed |
| US-20150158858-A1 | HETEROARYL DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158858-A1 | HETEROARYL DERIVATIVES | PDE4A, PDE4B, PDE3A | CHRM3 4/4885CHRNA7 86/4885BCHE 535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.