Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.72 |
| ▸ | CD69 | Q07108 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HRH2 | P25021 | 1/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.59 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.59 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.59 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.59 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.59 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 9/20 | 0.42 |
| ▸ | BCR | P11274 | 6/20 | 0.42 |
| ▸ | LYN | P07948 | 5/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16794206 | 0.90 | BTK (0.71) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL18170405 | 0.84 | BTK (1.00) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL16794064 | 0.82 | BTK (0.87) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL16794271 | 0.82 | BTK (0.59) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL18170415 | 0.82 | BTK (0.86) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL16794281 | 0.81 | BTK (0.56) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL16794157 | 0.80 | BTK (0.84) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL16793877 | 0.79 | BTK (0.69) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL16794500 | 0.78 | BTK (0.79) | BTKCD69JAK2CYP3A4HRH2 | |
| SCHEMBL16794508 | 0.78 | BTK (0.79) | BTKCD69JAK2CYP3A4HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080103-A1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | Biogen MA Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015089337-A1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN IDEC MA INC. (US) | 2015-06-18 | — | — | WO | disclosed |