Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.72 |
| ▸ | RAB9A | P51151 | 8/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 10/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | AHR | P35869 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CASP1 | P29466 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869991 | 0.84 | NPC1 (1.00) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL429754 | 0.84 | MAPT (1.00) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL6206238 | 0.83 | SMN1; SMN2 (0.72) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL16795004 | 0.82 | NPC1 (0.71) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL16794986 | 0.80 | MAPT (0.74) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL14172649 | 0.80 | NPC1 (0.47) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL14172757 | 0.80 | NPC1 (0.47) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL16794821 | 0.75 | MAPT (0.77) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL30979845 | 0.75 | MAPT (1.00) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL30979841 | 0.75 | MAPT (1.00) | NPC1SMN1; SMN2RAB9APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015088564-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |