Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.60 |
| ▸ | FYN | P06241 | 9/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679706 | 0.85 | PRKD3 (0.75) | CHEK2FYNPRKD3PRKD1PRKD2 | |
| SCHEMBL1679150 | 0.82 | CHEK2 (0.71) | CHEK2FYNCHEK1NEK1MAP4K4 | |
| SCHEMBL1679734 | 0.79 | CHEK2 (0.56) | CHEK2FYNPRKD3PRKD1PRKD2 | |
| SCHEMBL1679588 | 0.79 | PRKD3 (0.72) | CHEK2FYNPRKD3PRKD1PRKD2 | |
| SCHEMBL1679585 | 0.78 | PRKD3 (0.87) | CHEK2FYNPRKD3PRKD1PRKD2 | |
| SCHEMBL1679485 | 0.77 | PRKD3 (0.65) | CHEK2FYNPRKD3PRKD1PRKD2 | |
| SCHEMBL1679110 | 0.77 | PRKD3 (0.86) | CHEK2FYNPRKD3PRKD1PRKD2 | |
| SCHEMBL1679478 | 0.77 | PRKD3 (0.77) | CHEK2FYNPRKD3PRKD1PRKD2 | |
| SCHEMBL2750376 | 0.77 | ATR (0.54) | FYNPRKD3PRKD1PRKD2ATR | |
| SCHEMBL1679133 | 0.77 | PRKD3 (0.69) | CHEK2FYNPRKD3PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-04-28 | — | — | US | claimed |
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| WO-2008074997-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098325-A1 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS | PKD2, PKD1, BAZ2B | CHEK2 587/4885FYN 1665/4885PRKD3 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.