Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.64 |
| ▸ | JAK1 | P23458 | 20/20 | 0.64 |
| ▸ | JAK3 | P52333 | 20/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18302190 | 1.00 | JAK2 (0.64) | JAK2JAK1JAK3 | |
| SCHEMBL16795188 | 0.89 | JAK2 (0.66) | JAK2JAK1JAK3 | |
| SCHEMBL22364286 | 0.89 | JAK2 (0.59) | JAK2JAK1JAK3 | |
| SCHEMBL16795190 | 0.89 | JAK2 (0.66) | JAK2JAK1JAK3 | |
| SCHEMBL16795127 | 0.87 | JAK2 (0.66) | JAK2JAK1JAK3 | |
| SCHEMBL18302331 | 0.87 | JAK2 (0.66) | JAK2JAK1JAK3 | |
| SCHEMBL18302148 | 0.86 | JAK2 (0.85) | JAK2JAK1JAK3 | |
| SCHEMBL18302213 | 0.82 | JAK2 (0.66) | JAK2JAK1JAK3 | |
| SCHEMBL16795406 | 0.82 | JAK2 (0.66) | JAK2JAK1JAK3 | |
| SCHEMBL22364288 | 0.81 | JAK2 (0.47) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |