Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | PPARG | P37231 | 4/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.48 |
| ▸ | CPA1 | P15085 | 2/20 | 0.47 |
| ▸ | CPB1 | P15086 | 1/20 | 0.47 |
| ▸ | CPA3 | P15088 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16798274 | 0.88 | KMT2A (0.49) | KMT2APPARGEPHX2MEN1PPARA | |
| SCHEMBL7505398 | 0.85 | CPA1 (0.66) | CPA1CPB1CPA3CPB2CYP1A2 | |
| SCHEMBL9574107 | 0.85 | CPA1 (0.66) | CPA1CPB1CPA3CPB2CYP1A2 | |
| SCHEMBL16798223 | 0.84 | CPA1 (0.47) | KMT2APPARGEPHX2PPARACPA1 | |
| SCHEMBL4504708 | 0.84 | KMT2A (0.52) | KMT2APPARGEPHX2MEN1PPARA | |
| SCHEMBL1915429 | 0.84 | KMT2A (0.52) | KMT2APPARGEPHX2MEN1PPARA | |
| SCHEMBL1915428 | 0.84 | KMT2A (0.52) | KMT2APPARGEPHX2MEN1PPARA | |
| SCHEMBL11463940 | 0.82 | KMT2A (0.46) | KMT2APPARGMEN1PPARAALDH1A1 | |
| SCHEMBL28074267 | 0.82 | CPA1 (0.70) | KMT2APPARGEPHX2MEN1PPARA | |
| SCHEMBL4663230 | 0.81 | CYP1A2 (0.65) | KMT2APPARGEPHX2PPARABCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077401-A1 | SERINE/THREONINE KINASE INHIBITORS | Genentech, Inc. (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015085007-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2015-06-11 | — | — | WO | disclosed |