Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.87 |
| ▸ | LCK | P06239 | 4/20 | 0.74 |
| ▸ | EGFR | P00533 | 2/20 | 0.74 |
| ▸ | JAK3 | P52333 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16798531 | 1.00 | BTK (0.87) | BTKLCKEGFRJAK3 | |
| SCHEMBL16798675 | 0.94 | EGFR (0.83) | BTKLCKEGFRJAK3 | |
| SCHEMBL16798676 | 0.94 | EGFR (0.83) | BTKLCKEGFRJAK3 | |
| SCHEMBL16764465 | 0.93 | BTK (1.00) | BTKLCKEGFRJAK3 | |
| SCHEMBL16764965 | 0.93 | BTK (1.00) | BTKLCKEGFRJAK3 | |
| SCHEMBL16798743 | 0.91 | BTK (0.84) | BTKLCKEGFRJAK3 | |
| SCHEMBL16798744 | 0.91 | BTK (0.84) | BTKLCKEGFRJAK3 | |
| SCHEMBL16798601 | 0.89 | BTK (0.82) | BTKLCKEGFR | |
| SCHEMBL16798602 | 0.89 | BTK (0.82) | BTKLCKEGFR | |
| SCHEMBL16798694 | 0.89 | LCK (0.87) | BTKLCKEGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077388-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Pharmacyclics, LLC (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015084998-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2015-06-11 | — | — | WO | disclosed |