Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.65 |
| ▸ | CCND1 | P24385 | 9/20 | 0.43 |
| ▸ | CDK4 | P11802 | 5/20 | 0.43 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 14/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.39 |
| ▸ | CDK9 | P50750 | 4/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16802604 | 0.82 | MAPK8 (0.60) | MAPK8MAPK10CCND1CDK4CDK2 | |
| SCHEMBL16802602 | 0.79 | MAPK8 (0.61) | MAPK8MAPK10CCND1CDK4CDK2 | |
| SCHEMBL16799912 | 0.79 | MAPK8 (0.72) | MAPK8MAPK10CCND1CDK4CDK2 | |
| SCHEMBL18148268 | 0.79 | MAPK8 (1.00) | MAPK8MAPK10CDK2MAPK9 | |
| SCHEMBL16802603 | 0.79 | MAPK8 (1.00) | MAPK8MAPK10CDK2MAPK9 | |
| SCHEMBL18148252 | 0.79 | MAPK8 (0.76) | MAPK8MAPK10CCNT1CDK9MAPK9 | |
| SCHEMBL16802600 | 0.79 | MAPK8 (0.76) | MAPK8MAPK10CCNT1CDK9MAPK9 | |
| SCHEMBL18148272 | 0.77 | MAPK8 (0.65) | MAPK8MAPK10CDK2CDK9MAPK9 | |
| SCHEMBL16802598 | 0.77 | MAPK8 (0.65) | MAPK8MAPK10CDK2CDK9MAPK9 | |
| SCHEMBL5050255 | 0.68 | CDK2 (0.44) | MAPK8MAPK10CCND1CDK4CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3076789-A1 | NOVEL COMPOUNDS AS JNK KINASE INHIBITORS | The Scripps Research Institute (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015084936-A1 | NOVEL COMPOUNDS AS JNK KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-06-11 | — | — | WO | disclosed |