Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 18/20 | 0.61 |
| ▸ | KCNJ1 | P48048 | 17/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4549776 | 0.89 | KCNH2 (0.78) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196864 | 0.87 | KCNH2 (0.79) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196879 | 0.85 | KCNH2 (0.80) | KCNH2KCNJ1 | |
| SCHEMBL15196818 | 0.85 | KCNH2 (0.63) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196936 | 0.83 | KCNH2 (0.72) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196846 | 0.83 | KCNJ1 (0.78) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196881 | 0.81 | KCNH2 (0.65) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196883 | 0.81 | KCNJ1 (0.65) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196958 | 0.81 | KCNH2 (0.62) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL15196820 | 0.79 | KCNJ1 (0.64) | KCNH2KCNJ1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056859-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2015-06-16 | — | — | US | disclosed |