⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15561310 | 0.92 | — | — | |
| SCHEMBL21379305 | 0.85 | — | — | |
| SCHEMBL498251 | 0.72 | — | — | |
| SCHEMBL10652332 | 0.72 | — | — | |
| SCHEMBL498616 | 0.72 | — | — | |
| SCHEMBL28582310 | 0.70 | — | — | |
| SCHEMBL16597953 | 0.69 | — | — | |
| SCHEMBL1992561 | 0.67 | — | — | |
| SCHEMBL28311312 | 0.67 | — | — | |
| SCHEMBL12615012 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359358-B2 | Cyclohexyl azetidine derivatives as JAK inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-06-07 | — | — | US | claimed |
| US-20130045963-A1 | Cyclohexyl Azetidine Derivatives as JAK Inhibitors | INCYTE CORPORATION (US) | 2013-02-21 | — | — | US | claimed |
| WO-2013026025-A1 | CYCLOHEXYL AZETIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2013-02-21 | — | — | WO | claimed |
| US-9359358-B2 | Cyclohexyl azetidine derivatives as JAK inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-06-07 | — | — | US | disclosed |
| US-20130045963-A1 | Cyclohexyl Azetidine Derivatives as JAK Inhibitors | INCYTE CORPORATION (US) | 2013-02-21 | — | — | US | disclosed |
| WO-2013026025-A1 | CYCLOHEXYL AZETIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2013-02-21 | — | — | WO | disclosed |
| EP-2490698-A1 | MODULATION OF AXON DEGENERATION | F. Hoffmann-La Roche AG (CH) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050192-A1 | MODULATION OF AXON DEGENERATION | GENENTECH, INC. (US) | 2011-04-28 | — | — | WO | disclosed |
| US-7226941-B2 | Compound for treating angiogenesis | HIF BIO, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| EP-1646382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | HIF BIO INC. (US) | 2006-04-19 | — | — | EP | disclosed |
| US-20050187276-A1 | Compounds, compositions and methods | BIZBIOTECH CO., LTD. (KR) | 2005-08-25 | — | — | US | disclosed |
| WO-2005030121-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | HIF BIO, INC. (US) | 2005-04-07 | — | — | WO | disclosed |