Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 5/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1680094 | 0.91 | PIK3R1 (0.52) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL1680076 | 0.89 | PIK3CA (0.38) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL1680098 | 0.81 | PIK3CD (0.52) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL1680095 | 0.80 | PIK3CA (0.41) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL1680080 | 0.78 | PIK3CA (0.38) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL1680083 | 0.78 | PIK3CA (0.52) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL1680087 | 0.76 | PIK3CA (0.42) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL11899777 | 0.76 | PIK3CA (0.44) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL1680100 | 0.76 | PIK3CA (0.41) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 | |
| SCHEMBL1680106 | 0.76 | PIK3CA (0.41) | PIK3CBPIK3CAPIK3CDPIK3R1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483272-A2 | PI3K (DELTA) SELECTIVE INHIBITORS | Xcovery Holding Company LLC (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041399-A2 | PI3K (DELTA) SELECTIVE INHIBITORS | TYROGENEX, INC. (US) | 2011-04-07 | — | — | WO | claimed |
| EP-2483272-A2 | PI3K (DELTA) SELECTIVE INHIBITORS | Xcovery Holding Company LLC (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041399-A2 | PI3K (DELTA) SELECTIVE INHIBITORS | TYROGENEX, INC. (US) | 2011-04-07 | — | — | WO | disclosed |