Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16765882 | 0.99 | BTK (0.37) | BTKSYKMAPK8HTR1ADRD2 | |
| SCHEMBL16791398 | 0.91 | BTK (0.37) | BTKSYKMAPK8HTR1ADRD2 | |
| SCHEMBL16790973 | 0.89 | BRD4 (0.37) | BTKMAPK8CHRNB2CHRNA4HTR7 | |
| SCHEMBL16766621 | 0.88 | BTK (0.37) | BTKSYKMAPK8HTR7 | |
| SCHEMBL16790985 | 0.88 | BTK (0.35) | BTKMAPK8 | |
| Hydrochloric Acid SCHEMBL16766354 | 0.87 | BTK (0.36) | BTKSYKMAPK8HTR7 | |
| SCHEMBL107748 | 0.87 | MAPK8 (0.45) | BTKMAPK8 | |
| SCHEMBL16766386 | 0.86 | BTK (0.41) | BTKSYKMAPK8MKNK1MKNK2 | |
| SCHEMBL16791403 | 0.85 | BTK (0.52) | BTK | |
| SCHEMBL16790980 | 0.84 | BTK (0.41) | BTKSYKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077384-B1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | HOFFMANN LA ROCHE (CH) | 2017-09-06 | — | — | EP | disclosed |
| WO-2015082583-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-11 | — | — | WO | disclosed |