Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 2/20 | 0.58 |
| ▸ | NR2C2 | P49116 | 2/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.50 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | TYK2 | P29597 | 4/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PAK4 | O96013 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30967733 | 0.75 | NR2C2 (1.00) | HCKNR2C2MAP4K4MAP4K2BTK | |
| SCHEMBL16809262 | 0.75 | NR2C2 (1.00) | HCKNR2C2MAP4K4MAP4K2BTK | |
| SCHEMBL16793977 | 0.73 | TYK2 (0.56) | ALKCDK19JAK2JAK1TYK2 | |
| SCHEMBL4561175 | 0.72 | JAK3 (0.53) | ALKCDK19JAK2JAK1TYK2 | |
| SCHEMBL4559693 | 0.71 | ALK (0.62) | ALKCDK19JAK2JAK1TYK2 | |
| SCHEMBL23281912 | 0.71 | ABL1 (0.49) | ALKCDK19JAK2JAK1TYK2 | |
| SCHEMBL23275907 | 0.70 | CDK4 (0.49) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL29901235 | 0.70 | CDK4 (0.49) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL29622852 | 0.70 | ALK (0.57) | ALKCDK19JAK2JAK1TYK2 | |
| SCHEMBL29676559 | 0.70 | JAK3 (0.57) | ALKCDK19JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089479-A1 | METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-06-18 | — | — | WO | disclosed |