Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18286469 | 0.93 | SMO (0.58) | SMOMAPK14SSTR5DRD4HPGDS | |
| SCHEMBL16811807 | 0.93 | SMO (0.64) | SMOMAPK14DRD4LMNASMN1; SMN2 | |
| SCHEMBL16811783 | 0.92 | SMO (0.59) | SMOSSTR5DRD4HPGDSNPC1 | |
| SCHEMBL16811799 | 0.92 | SMO (0.59) | SMOSSTR5DRD4HPGDSNPC1 | |
| SCHEMBL16811831 | 0.91 | SMO (0.74) | SMOMAPK14SSTR5DRD4NPC1 | |
| SCHEMBL16811851 | 0.91 | SMO (0.62) | SMOMAPK14SSTR5DRD4HPGDS | |
| SCHEMBL16811800 | 0.89 | SMO (0.56) | SMOMAPK14SSTR5DRD4HPGDS | |
| SCHEMBL16812724 | 0.89 | SMO (0.52) | SMOMAPK14SSTR5DRD4HPGDS | |
| SCHEMBL18286583 | 0.88 | SMO (0.52) | SMOMAPK14SSTR5DRD4HPGDS | |
| SCHEMBL16812011 | 0.88 | SMO (0.81) | SMOMAPK14SSTR5DRD4ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150166509-A1 | SMOOTHENED MODULATORS AND METHODS OF USE THEREOF | UNIV DUKE (US) | 2015-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166509-A1 | SMOOTHENED MODULATORS AND METHODS OF USE THEREOF | SMO, SHH, GLI1 | SMO 1/4885MAPK14 1495/4885SSTR5 1894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.