Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 12/20 | 0.50 |
| ▸ | PDE1A | P54750 | 5/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16822562 | 1.00 | PDE1B (0.50) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822602 | 1.00 | PDE1B (0.50) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822537 | 0.92 | PDE1B (0.48) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822535 | 0.92 | PDE1B (0.48) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822608 | 0.92 | PDE1B (0.48) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822538 | 0.90 | PDE1B (0.48) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822539 | 0.90 | PDE1B (0.48) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822612 | 0.90 | PDE1B (0.48) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822544 | 0.87 | PDE1B (0.46) | PDE1BPDE1APDE1CLMNAKDM4E | |
| SCHEMBL16822640 | 0.87 | PDE1B (0.46) | PDE1BPDE1APDE1CLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083607-B1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2019-04-24 | — | — | EP | claimed |
| US-10030007-B2 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-07-24 | — | — | US | claimed |
| US-20170267664-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-09-21 | — | — | US | claimed |
| US-9701665-B2 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2017-07-11 | — | — | US | claimed |
| US-20160318910-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2016-11-03 | — | — | US | claimed |
| EP-3083607-A1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2016-10-26 | — | — | EP | claimed |
| WO-2015091805-A1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2015-06-25 | — | — | WO | claimed |
| US-20150175584-A1 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-25 | — | — | US | claimed |
| EP-3083607-B1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2019-04-24 | — | — | EP | disclosed |
| US-10030007-B2 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-07-24 | — | — | US | disclosed |
| US-20170267664-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-09-21 | — | — | US | disclosed |
| US-9701665-B2 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2017-07-11 | — | — | US | disclosed |
| US-20160318910-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2016-11-03 | — | — | US | disclosed |
| EP-3083607-A1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015091805-A1 | QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2015-06-25 | — | — | WO | disclosed |
| US-20150175584-A1 | Quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10030007-B2 | Quinazolin-THF-amines as PDE1 inhibitors | PDE12, PDE3A, PDE5A | PDE1B 15/4885PDE1A 12/4885PDE1C 29/4885 |
| US-20150175584-A1 | Quinazolin-THF-amines as PDE1 inhibitors | PDE12, PDE3A, PDE5A | PDE1B 15/4885PDE1A 13/4885PDE1C 29/4885 |
| US-20160318910-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | PDE12, PDE3A, PDE5A | PDE1B 15/4885PDE1A 13/4885PDE1C 29/4885 |
| US-20170267664-A1 | Quinazolin-THF-Amines as PDE1 Inhibitors | PDE12, PDE3A, PDE5A | PDE1B 15/4885PDE1A 12/4885PDE1C 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.