Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | CDK7 | P50613 | 2/20 | 0.54 |
| ▸ | BLK | P51451 | 2/20 | 0.54 |
| ▸ | CCNH | P51946 | 2/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.54 |
| ▸ | NRAS | P01111 | 5/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16824756 | 0.91 | FLT3 (0.51) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL1995527 | 0.89 | IRAK4 (0.54) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL12616166 | 0.89 | IRAK4 (0.54) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL1994861 | 0.87 | FLT3 (0.51) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL1994864 | 0.87 | FLT3 (0.51) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL1996301 | 0.85 | FLT3 (0.49) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL2051378 | 0.85 | FLT3 (0.49) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL2054238 | 0.84 | FLT3 (0.49) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL2054237 | 0.84 | FLT3 (0.49) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL16824628 | 0.84 | IRAK4 (0.45) | FLT3IRAK4IRAK1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091531-A1 | IMIDAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-25 | — | — | WO | disclosed |