Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1682528 | 1.00 | ESR1 (0.33) | ESR1ESR2 | |
| SCHEMBL11899122 | 0.86 | ESR1 (0.36) | ESR1ESR2 | |
| SCHEMBL11899123 | 0.86 | ESR1 (0.36) | ESR1ESR2 | |
| SCHEMBL11898889 | 0.84 | ESR1 (0.31) | ESR1ESR2 | |
| SCHEMBL1682605 | 0.84 | HSP90AB1 (0.35) | ESR1ESR2 | |
| SCHEMBL11899095 | 0.84 | HSP90AB1 (0.35) | ESR1ESR2 | |
| SCHEMBL1682380 | 0.84 | ESR1 (0.31) | ESR1ESR2 | |
| SCHEMBL11899890 | 0.82 | ESR1 (0.31) | ESR1ESR2 | |
| SCHEMBL1682385 | 0.82 | ESR1 (0.31) | ESR1ESR2 | |
| SCHEMBL11899902 | 0.82 | ESR1 (0.36) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486018-B1 | SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO PHARMA AB (SE) | 2019-04-24 | — | — | EP | disclosed |
| US-8921402-B2 | Substituted pyrazoles as estrogen receptor ligands | KARO BIO AB (SE) | 2014-12-30 | — | — | US | disclosed |
| US-20140128435-A1 | SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2014-05-08 | — | — | US | disclosed |
| EP-2486018-A1 | SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011042475-A1 | SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128435-A1 | SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS | GPER1, ESR1, ESRRA | ESR1 2/4885ESR2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.