Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL16783669 | 0.98 | PIK3CD (0.45) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16806454 | 0.93 | PIK3CD (0.49) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783668 | 0.92 | PIK3CD (0.40) | PIK3CDPIK3CBPIK3CGPIK3CABTK | |
| SCHEMBL16783729 | 0.92 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16806461 | 0.89 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783411 | 0.88 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| Hydrochloric Acid SCHEMBL16783872 | 0.88 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783873 | 0.87 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL21327908 | 0.87 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 | |
| SCHEMBL16783842 | 0.87 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083617-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-11 | — | — | EP | disclosed |
| EP-3083617-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015091685-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-25 | — | — | WO | disclosed |