Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511496 | 0.90 | IKBKB (0.63) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10052116 | 0.87 | IKBKB (0.68) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3670051 | 0.86 | IKBKB (0.58) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1427929 | 0.83 | IKBKB (0.58) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL5898698 | 0.83 | IKBKB (0.71) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1428022 | 0.83 | IKBKB (0.71) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3507771 | 0.81 | IKBKB (0.73) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1428734 | 0.80 | IKBKB (0.58) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1684109 | 0.80 | IKBKB (0.67) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1428039 | 0.80 | IKBKB (0.71) | IKBKBGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046793-A1 | NOVEL JAK3 INHIBITOR CONTAINING, AS ACTIVE INGREDIENT, THIOPHENE DERIVATIVE HAVING UREIDO GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | 参天製薬株式会社 (JP) | 2012-04-12 | — | — | WO | disclosed |