Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | PRKX | P51817 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21718924 | 0.83 | SYK (0.35) | TAAR1DYRK1A | |
| SCHEMBL21718391 | 0.80 | NQO1 (0.41) | LTA4HESR1 | |
| SCHEMBL26425196 | 0.79 | CXCR1 (0.35) | — | |
| SCHEMBL23067933 | 0.77 | TAAR1 (0.48) | SMN1; SMN2TAAR1LTA4HPLA2G2AAKT1 | |
| SCHEMBL21718923 | 0.77 | MAPT (0.50) | SMN1; SMN2 | |
| SCHEMBL21718780 | 0.77 | TAAR1 (0.32) | TAAR1 | |
| SCHEMBL1683223 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2TAAR1LTA4HPLA2G2APDK2 | |
| SCHEMBL4579541 | 0.76 | HTR1D (0.48) | SMN1; SMN2TAAR1LTA4HPLA2G2AHTR1D | |
| SCHEMBL21718878 | 0.76 | MAOB (0.39) | SMN1; SMN2 | |
| SCHEMBL21718776 | 0.76 | TAAR1 (0.32) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045729-A1 | IMIDAZO [1, 2 -A] PYRIDINE AND PYRAZOLO [1, 5 -A] PYRIDINE DERIVATIVES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-04-12 | — | — | WO | disclosed |