SCHEMBL16833740

SCHEMBL16833740

Cc1nn(Cc2ccc(C#N)cc2)c(C(F)(F)F)c1N

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 10/20 0.48
GAA P10253 1/20 0.46
GFER P55789 1/20 0.46
TSHR P16473 1/20 0.45
KDM4E B2RXH2 1/20 0.43
SLC2A3 P11169 9/20 0.41
SLC2A4 P14672 8/20 0.41
SLC2A2 P11168 4/20 0.41
CYP19A1 P11511 2/20 0.41
CYP11B2 P19099 2/20 0.41
CYP11B1 P15538 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
KCNK3 O14649 1/20 0.38
AR P10275 2/20 0.38
KCNH2 Q12809 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16832838 0.84 SLC2A1 (0.39) SLC2A1TSHRSLC2A3SLC2A4SLC2A2
SCHEMBL16832421 0.82 GAA (0.68) SLC2A1GAAGFERTSHRKDM4E
SCHEMBL16855500 0.79 SLC2A1 (0.42) SLC2A1GAASLC2A3SLC2A4SLC2A2
SCHEMBL16832435 0.79 MAPT (0.49) SLC2A1GAASLC2A3SLC2A4SLC2A2
SCHEMBL16832309 0.79 SLC2A1 (0.52) SLC2A1GAAGFERSLC2A3SLC2A4
SCHEMBL16832458 0.78 GAA (0.48) SLC2A1GAAGFERTSHRKDM4E
SCHEMBL16832841 0.77 GAA (0.47) SLC2A1GAAGFERTSHRKDM4E
SCHEMBL16833222 0.74 SLC2A1 (0.44) SLC2A1SLC2A3SLC2A4SLC2A2CYP19A1
SCHEMBL16832331 0.73 SLC2A1 (0.43) SLC2A1SLC2A3SLC2A4SLC2A2CYP19A1
SCHEMBL16832433 0.71 SLC2A1 (0.70) SLC2A1GAAGFERKDM4EPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170037028-A1 GLUCOSE TRANSPORT INHIBITORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-02-09 US disclosed
US-20170037028-A1 GLUCOSE TRANSPORT INHIBITORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-02-09 US disclosed
US-20170037028-A1 GLUCOSE TRANSPORT INHIBITORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-02-09 US disclosed
EP-3083598-A1 GLUCOSE TRANSPORT INHIBITORS Bayer Pharma Aktiengesellschaft (DE) 2016-10-26 EP disclosed
CN-106029647-A Glucose transport inhibitors 拜耳制药股份公司 2016-10-12 CN disclosed
WO-2015091428-A1 GLUCOSE TRANSPORT INHIBITORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-06-25 WO disclosed
WO-2015091428-A1 GLUCOSE TRANSPORT INHIBITORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-06-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170037028-A1 GLUCOSE TRANSPORT INHIBITORS SLC2A1, SLC2A2, SLC2A4 SLC2A1 1/4885GAA 86/4885GFER 2535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.