Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.47 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.47 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.47 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.47 |
| ▸ | KCNN4 | O15554 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3447426 | 0.81 | PDE2A (0.43) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL16833488 | 0.81 | MEN1 (0.53) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1NPC1 | |
| SCHEMBL16846266 | 0.81 | MEN1 (0.53) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1NPC1 | |
| SCHEMBL16833939 | 0.80 | KCNN4 (0.36) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KCNN4 | |
| SCHEMBL16834109 | 0.80 | KCNN4 (0.36) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KCNN4 | |
| SCHEMBL16834115 | 0.80 | KCNN4 (0.36) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KCNN4 | |
| SCHEMBL9951922 | 0.79 | AR (0.36) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KCNN4 | |
| SCHEMBL9953037 | 0.79 | PTGDR2 (0.40) | NPC1RAB9AGAA | |
| SCHEMBL16834048 | 0.78 | GUCY1B2 (0.38) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KCNN4 | |
| SCHEMBL26907235 | 0.78 | CYP3A4 (0.49) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083644-B1 | 5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES | HOFFMANN LA ROCHE (CH) | 2019-03-13 | — | — | EP | disclosed |
| US-9605006-B2 | 5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines | HOFFMANN-LA ROCHE INC. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20160318952-A1 | 5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES | HOFFMANN-LA ROCHE INC. (US) | 2016-11-03 | — | — | US | disclosed |
| EP-3083644-A1 | 5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES | F. Hoffmann-La Roche AG (CH) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015091595-A1 | 5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318952-A1 | 5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES | BACE1, BACE2, PSEN1 | GUCY1B2 1557/4885GUCY1A2 1290/4885GUCY1A1 817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.